Zolpidem at supratherapeutic doses can cause drug abuse, dependence and withdrawal seizure.
نویسندگان
چکیده
Zolpidem is a non-benzodiazepine hypnotic drug, acts selectively through omega 1 receptors of GABAA. It is thought to be safer than benzodiazepines but we report a case of zolpidem drug abuse, dependence and withdrawal seizure.
منابع مشابه
Zolpidem dependence and withdrawal seizure--report of two cases.
Zolpidem is a non-benzodiazepine property which binds selectively to the ?1-GABAA receptors, and has been widely prescribed to patients suffering from insomnia. We report two cases of zolpidem dependence with withdrawal seizure in the Asian population. The first case is a 43-year-old woman who took zolpidem up to the dosage of 200 to 400 mg per night. The second case is a 35-year-old woman who ...
متن کاملZolpidem Dependency and Withdrawal Seizure: A Case Report Study
INTRODUCTION Zolpidem is a short acting inducer of sleep and thought to lack benzodiazepine properties such as anxiolysis, anticonvulsion, muscle relaxation and side effects such as dependency. Recently, some cases of Zolpidem abuse and dependency have been reported. In review of literature, we found that the lowest reported dosage of Zolpidem, which caused dependency, was 160 mg daily. CASE ...
متن کاملZolpidem dependence, abuse and withdrawal: A case report
Zolpidem, a nonbenzodiazepine hypnotic, binds to the benzodiazepine binding site on the gamma-aminobutyric acid type A (GABA-A) receptors. Many studies have reported efficacy and safety of zolpidem in treatment of insomnia, low abuse, and dependence capability. However, many cases of zolpidem abuse and dependence were reported around the world. This case showed that zolpidem can exert abuse cap...
متن کاملPM297. High-dose zolpidem dependence and detoxification from withdrawal symptoms using diazepam
Objective: Efforts to promote the cessation of harmful alcohol use are hindered by the affective and physiological components of alcohol withdrawal (AW), which can include life-threatening seizures. Although previous studies of AW and relapse have highlighted the critical importance of the N-methyl-D-aspartate receptor (NMDAR) subunit GluN2B and the detrimental role of stress, little is known a...
متن کاملHigh-dose zolpidem dependence and detoxification from withdrawal symptoms using diazepam
Objective: Efforts to promote the cessation of harmful alcohol use are hindered by the affective and physiological components of alcohol withdrawal (AW), which can include life-threatening seizures. Although previous studies of AW and relapse have highlighted the critical importance of the N-methyl-D-aspartate receptor (NMDAR) subunit GluN2B and the detrimental role of stress, little is known a...
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ورودعنوان ژورنال:
- The Journal of the Association of Physicians of India
دوره 53 شماره
صفحات -
تاریخ انتشار 2005